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生物统计学和生物信息学最新进展 英文2025|PDF|Epub|mobi|kindle电子书版本百度云盘下载

生物统计学和生物信息学最新进展 英文
  • 范剑青，林希虹，刘军主编 著
  • 出版社： 北京：高等教育出版社
  • ISBN：9787040247558
  • 出版时间：2008
  • 标注页数：280页
  • 文件大小：23MB
  • 文件页数：291页
  • 主题词：生物统计－文集－英文；生物信息论－文集－英文

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图书目录

Part Ⅰ Analysis of Survival and Longitudinal Data3

Chapter 1 Non-and Semi-Parametric Modeling in Survival Analysis Jianqing Fan,Jiancheng Jiang3

1 Introduction3

2 Cox's type of models4

3 Multivariate Cox's type of models14

4 Model selection on Cox's models24

5 Validating Cox's type of models27

6 Transformation models28

7 Concluding remarks30

References30

Chapter 2 Additive-Accelerated Rate Model for Recurrent Event Donglin Zeng,Jianwen Cai35

1 Introduction35

2 Inference procedure and asymptotic properties37

3 Assessing additive and accelerated covariates40

4 Simulation studies41

5 Application42

6 Remarks43

Acknowledgements44

Appendix44

References48

Chapter 3 An Overview on Quadratic Inference Function Approaches for Longitudinal Data John J.Dziak,Runze Li,Annie Qu49

1 Introduction49

2 The quadratic inference function approach51

3 Penalized quadratic inference function56

4 Some applications of QIF60

5 Further research and concluding remarks65

Acknowledgements68

References68

Chapter 4 Modeling and Analysis of Spatially Correlated Data Yi Li73

1 Introduction73

2 Basic concepts of spatial process76

3 Spatial models for non-normal/discrete data82

4 Spatial models for censored outcome data88

5 Concluding remarks96

References96

Part Ⅱ Statistical Methods for Epidemiology103

Chapter 5 Study Designs for Biomarker-Based Treatment Selection Amy Laird,Xiao-Hua Zhou103

1 Introduction103

2 Definition of study designs104

3 Test of hypotheses and sample size calculation108

4 Sample size calculation111

5 Numerical comparisons of efficiency116

6 Conclusions118

Acknowledgements121

Appendix122

References126

Chapter 6 Statistical Methods for Analyzing Two-Phase Studies Jinbo Chen127

1 Introduction127

2 Two-phase case-control or cross-sectional studies130

3 Two-phase designs in cohort studies136

4 Conclusions149

References151

Part Ⅲ Bioinformatics159

Chapter 7 Protein Interaction Predictions from Diverse Sources Yin Liu,Inyoung Kim,Hongyu Zhao159

1 Introduction159

2 Data sources useful for protein interaction predictions161

3 Domain-based methods163

4 Classification methods169

5 Complex detection methods172

6 Conclusions175

Acknowledgements175

References175

Chapter 8 Regulatory Motif Discovery:From Decoding to Meta-Analysis Qing Zhou,Mayetri Gupta179

1 Introduction179

2 A Bayesian approach to motif discovery181

3 Discovery of regulatory modules184

4 Motif discovery in multiple species189

5 Motif learning on ChIP-chip data195

6 Using nucleosome positioning information in motif discovery201

7 Conclusion204

References205

Chapter 9 Analysis of Cancer Genome Alterations Using Single Nucleotide Polymorphism(SNP)Microarrays Cheng Li,Samir Amin209

1 Background209

2 Loss of heterozygosity analysis using SNP arrays212

3 Copy number analysis using SNP arrays216

4 High-level analysis using LOH and copy number data224

5 Software for cancer alteration analysis using SNP arrays229

6 Prospects231

Acknowledgements231

References231

Chapter 10 Analysis of ChIP-chip Data on Genome Tiling Microarrays W.Evan Johnson,Jun S.Liu,X.Shirley Liu239

1 Background molecular biology239

2 A ChIP-chip experiment241

3 Data description and analysis244

4 Follow-up analysis249

5 Conclusion254

References254

Subject Index259

Author Index261

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