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Section 1 CANCER BIOLOGY1

1. Molecular Biology [Barrett J. Rollins, Todd R. Golub, Kornelia Polyak, Charles D. Stiles]1

2. Cell Proliferation, Differentiation, and Apoptosis [Michael Andreeff, David W. Goodrich, Arthur B. Pardee]17

3. Growth Factor Signal Transduction in Cancer [Paolo Fedi, Alec Kimmelman, Stuart A. Aaronson]33

4. Oncogenes [Marco A. Pierotti, Steven A. Schichman, Gabriella Sozzi, Carlo M. Croce]56

5. Tumor Suppressor Gene Defects in Human Cancer [Eric R. Fearon, Bert Vogelstein]67

6. Recurring Chromosome Rearrangements in Human Cancer [Olufunmilayo I. Olopade, Olatoysi M. Sobulo, Janet D. Rowley]88

7. Biochemistry of Cancer [Raymond W. Ruddon]108

8. Invasion and Metastases [Lance A. Liotta, Elise C. Kohn]121

9. Tumor Angiogenesis [Judah Folkman]132

Section 2 TUMOR IMMUNOLOGY153

10. Tumor Immunology [Jeffrey Schlom, Scott I. Abrams]153

11. Genetic Predisposition to Cancer [Marcia S. Brose, Tom Smyrk, Barbara Weber, Henry T. Lynch]168

Section 3 CANCER ETIOLOGY168

12. Chemical Carcinogenesis [Ainsley Weston, Curtis C. Harris]185

13. Hormones and the Etiology of Cancer [Brian E. Henderson, Leslie Bernstein, Ronald K. Ross]195

14. Ionizing Radiation [John B. Little]207

15. Ultraviolet Radiation Carcinogenesis [James E. Cleaver. David L. Mitchell]219

16. Physical Carcinogens [Cesare Maltoni, Franco Minardi,James F. Holland]229

17. Trauma and Inflammation [John F. Gaeta]235

18. Tumor Viruses [Howard A. Fine, Joseph G. Sodroski]237

19. Herpesviruses [Jeffrey I. Cohen]252

20. Papillomaviruses and Cervical Neoplasia [Catherine M. McLachlin, Christopher P. Crum]259

21. Hepatitis Virrses [Max W. Sung, Swan N. Thung, George Acs]266

22. Parasites [Piero Mustacchi]277

Section 4 CANCER EPIDEMIOLOGY283

23. Cancer Epidemiology [Michael J. Thun, Phyllis A. Wingo]283

24. Theory and Practice of Clinical Trials [Marvin Zelen]298

Section 5 THEORY AND PRACTICE OF CLINICAL TRIALS298

Section 6 CANCER PREVENTION314

25. Prevention of Tobacco-Related Cancers [Paul F. Engstrom, Margie Clapper, Robert Schnoll, C. Tracy Orleans]314

26. Nutrition in the Etiology and Prevention of Cancer [Steven K. Clinton, Elizabeth C. Miller, Edward L. Gioannucci]328

27. Chemoprevention of Cancer [Michael B. Sporn, Scott M. Lippman]351

Section7 CANCER SCREENING AND EARLY DETECTION362

28. Cancer Screening and Early Detection [Harmon J. Eyre, Robert A. Smith, Curtis J. Mettlin]362

Section 8 PRINCIPLES OF CANCER PATHOLOGY384

29. Principles of Cancer Pathology [James L. Connolly, Stuart J. Schnitt, Helen H. Wang, Ann M. Dvorak, Harold F. Dvorak]384

Section 9 PRINCIPLES OF IMAGING400

30. Principles of Imaging [Richard J. Steckel]400

a. Imaging Cancer of Unknown Primary Site [A. Robert Kagan, Richard J. Steckel]403

b. Imaging Neoplasms of the Head and Neck and Central Nervous System [Robert B. Lufkin]405

c. Imaging Neoplasms of the Thorax [Poonam V. Batra]409

d. Imaging Neoplasms of the Abdomen and Pelvis [Robert A. Halvorsen Jr, William M. Thompson]413

e. Cross-Sectional Imaging of Musculoskeletal Neoplasms [Leanne L. Seeger]418

f. Imaging the Breast [Lawrence W. Bassett]420

g. Ultrasound in Cancer Medicine [Edward G. Grant]428

h. Radionuclide Imaging in Cancer Medicine [Randall A. Hawkins]433

i. Perspectives in Imaging [Richard J. Steckel]439

31. Interventional Radiology for the Cancer Patient [Marshall Hicks, Chusilp Charnsangavej, Michael Wallace]440

Section 10 PRINCIPLES OF SURGICAL ONCOLOGY448

32. Principles of Surgical Oncology [Raphael E. Pollock, Donald L. Morton]448

33. Vascular Access in Cancer Patients [Michail Shafir]459

Section 11 PRINCIPLES OF RADIATION ONCOLOGY465

34. Physical and Biologic Basis of Radiation Oncology [Arno J. Mundt, John C. Roeske, Ralph R. Weichselbaum]465

35. Principles of Hyperthermia [Daniel S. Kapp, George M. hahn, Robert W. Carlson]479

36. Photodynamic Therapy of Cancer [Tayyaba Hasan, Anne C.E. Moor, Bernard Ortel]489

Section 12 PRINCIPLES OF MEDICAL ONCOLOGY503

37. Principles of Medical Oncology [James F. Holland, Emil Frei Ⅲ,Donald W. Kufe, Robert C. Bast Jr]503

Section 13 PRINCIPLES OF CHEMOTHERAPY511

38. Cytokinetics [Teresa Ann Gilewski, Chau Dang, Antonella Surbone, Larry Norton]511

39. Drug Resistance and its Clinical Circumvention [Charles S. Morrow, Kenneth H. Cowan]539

40. Principles of Dose, Schedule, and Combination Chemotherapy [Emil Frei Ⅲ, Karen H. Antman]556

41. Regional Chemotherapy [Maurie Markman]569

42. Animal Models in Developmental Therapeutics [Samir N. Khleif, Gregory A. Curt]573

43. In Vitro and In Vivo Predictive Tests [Axel-R. Hanauska, Daniel D. Von Hoff]585

44. Pharmacology [Mark J. Ratain, William Plundett]589

45. Toxicology by Organ System [Michael R. Grever, Charles K. Grieshaber]602

Section 14 CHEMOTHERAPEUT0IC AGENTS612

46. Folate Antagonists [Barton A. Kamen, Peter D. Cole, Joseph R. Bertino]612

47. Pyrimidine and Purine Antimetabolites [Giuseppe Pizzorno, Robert E. Handschumacher, Yung-Chi Cheng]625

48. Alkylating Agents and Platinum Antitumor Compounds [D. Michael Colvin]648

49. Anthracyclines and DNA Intercalators/Epipodophyllotoxins/DNA Topoisomerases [Eric H. Rubin, William N. Hait]670

50. Microtubule-Targeting Anticancer Drugs Derived from Plants and Microbes: Vinca Alkaloids, Taxanes, and Epothilones [William T. Beck, Carol E. Cass, Peter J. Houghton]680

51. Asparaginase [JoAnne Kurtzberg]699

Section 15 PRINCIPLES OF ENDOCRINE THERAPY706

52. Steroid Hormone Binding and Hormone Receptors [Eugene R. DeSombre, Elwood V. Jensen]706

53. Hypothalamic and Other Peptide Hormones [Andrew V. Schally, Ana Maria Comaru- Schally]715

54. Corticosteroids [Lorraine I. Mckay, John A. Cidlowski]730

55. Estrogens and Antiestrogens [V. Craig Jordan]743

56. Clinical Use of Aromatase Inhibitors in Breast Carcinoma [Harold A. Harvey]751

57. Progestins [Kenneth S. McCarty JR, Kenneth S. McCarty Sr]760

58. Androgen Deprivation Strategies in the Treatment of Advanced Prostate Cancer[Samuel R. Denmeade, John T.Isaacs]765

59. Paraneoplastic Syndromes [William D. Odell]777

60. Immunostimulants [Robert C. Bast Jr, Donald L. Morton]790

Section 16 PRINCIPLES OF BIOTHERAPEUTICS790

61. Active Specific Immunotherapy with Vaccines [Mepur H. Ravindranath, Donald L. Morton]800

62. Interferons [Ernest C. Borden, Bryan R.G. Williams]815

63. Cytokines: Biology and Applications in Cancer Medicine [Elizabeth A. Grimm]825

64. Hematoopoietic Growth Factors [Razeller Kurzrock]835

65. Monoclonal Serotherapy [Robert C. Bast Jr., Michael R. Zalutsky, Robert J. Kreitman, Edward A. Sansville, Arthur R. Frandel]860

Section 17 PRINCIPLES OF GENE THERAPY876

66. Cancer Gene Therapy [Donald W. Kufe, Sunil Advanti, Ralph Weichselbaum]876

Section 18 PRINCIPLES OF BONE MARROW TRANSPLANTATION890

67. Autologous Bone Marrow and Stem Cell Transplantation [William P. Peters, Caroline Hamm, Roy D. Baynes]890

68. Transplantation of Allogeneic Hematopoietic Cells for the Treatment of Malignancies [Richard J. O Reilly, Esperanza B. Papadopoulos, Trudy N.Small]911

Section 19 PRINCIPLES OF PSYCHO-ONCOLOGY943

69. Principles of Psycho-Oncology [Jimmie C. Holland, Jane Gooen-Piels]943

70. Principles of Oncology Nursing [Mary Johnson, Connie Henke Yarbro]959

Section 20 PRINCIPLES OF ONCOLOGY NURSING959

Section 21 PRINCIPLES OF CANCER REHABILITATION MEKICINE971

71. Principles of Cancer Rehabilitation Medicine [Kristjan T. Ragnarsson, David C. Thomas]971

Section 22 PRINCIPLES OF MULTIDISCIPLINARY MANAGEMENT986

72. Principles of Multidisciplinary Management [James F. Holland, Emil Frei Ⅲ,Donald W. Kufe, Robert C. Bast Jr., Raphael E. Pollock, Ralph R. Weichselbarm]986

73. Palliative Care [Alan C. Carver, Kathleen M. Foley]992

Section 23 PRINCIPLES OF SOCIETAL ONCOLOGY1001

74. Ethical Aspects of Caring for Patients with Cancer [Ezekiel J. Emanuel, Steven Joffe]1001

75. Legal Aspects of Cancer [Joseph M. Taraska]1017

76. The Government and Cancer Medicine [John E. Ultmann, Marguerite Donoghue Baxter, Terry Lierman]1025

77. Clinical Oncology in a Changing Health Care Environment [Martin N. Raber, Joseph S. Bailes]1035

78. Outcomes Assessment [Jane C. Weeks]1039

79. Questionable Cancer Therapies [Barrie R. Cassileth]1045

80. Neoplasms of the Central Nervous System [Michael D. Prados]1055

Section 24 NEOPLASMS OF THE CENTRAL NERVOUS SYSTEM1055

Section 25 NEOPLASMS OF THE EYE1083

81. Neoplasms of the Eye [David H. Abramson, Ira J. Dunkel. Beryl McCormick]1083

Section 26 NEOPLASMS OF THE ENDOCRINE GLANDS1097

82. Pituitary Neoplasms [Aviva Abosch, Charles B. Wilson]1097

83. Neoplasms of the Thyroid [Steven I. Sherman, Ann M, Gillenwater]1105

84. Neoplasms of the Adrenal Cortex [David E. Schteingart]1115

85. Neoplasms of the Neuroendocrine System and Neoplasms of the Gastroenteropancreatic Endocrine System [Larry K. Kvols, Roger R. Perry, Aaron I. Vinik Li-Teh Wu, Phillippe Chaninian Stephen B. Baylin, Norman W. Thompson]1121

Section 27 NEOPLASMS OF THE HEAD AND NECK1173

86.Head and Neck Cancer[Gary L.Clayman,Scott M.Lippman,George E.Laramore,Waun Ki Hong]1173

87.Odontogenic Tumors[George Thomas Gallagher,Gerald Shklar]1221

Section 28 NEOPLASMS OF THE THORAX1227

88. Cancer of the Lung [Ara A. Vaporciyan, Jonathan C. Nesbitt, Jin Soo Lee, Craig W. Stevens, Ritsuko Komaki, Jack A. Roth]1227

89. Malignant Mesothelioma [A. Philippe Chahinian, Harvey I. Pass]1293

90. Thymomas and Thymic Tumors [A. Philippe Chahinian]1313

91. Tumors of the Heart and Great Vessels [A. Philippe Chahinian, David E. Gutstein, Valentin Fuster]1319

92. Primary Germ Cell Tumors of the Thorax [John D. Hainsworth, F. Anthony Greco]1322

93. Metastatic Tumors in the Thorax [Donald L. Morton, Perry Shen]1329

Section 29 NEOPLASMS OF THE ALIMENTARY CANAL1340

94. Neoplasms of the Esophagus [Mark K. Ferguson]1349

95. Neoplasms of the Stomach [Howard W. Bruckner, John C. Morris, Paul Mansfield]1355

96. Primary Neoplasms of the Liver [Paul F. Engstrom, Elin Sigurdson, Alison A. Evans]1391

97. Treatment of Liver Metastases [Nancy E. Kemeny, Yuman Fong]1402

98. The Gallbladder [Steven A. Curldy]1415

99. Diagnosis and Management of Biliary Tract Cancer [Steven A. Curley]1422

100. Neoplasms of the Ampulla of Vater [Douglas B.Evans, Robert A. Wolff]1431

101. Neoplasms of the Exocrine Pancreas [Robert A. Wolff, James L. Abbruzzese, Douglas B. Evans]1436

102. Neoplasms of the Small Intestine, Vermiform Appendix, and Peritoneum [Erik Barquist, Michael Zinner]1465

103. Adenocarcinoma of the Colon and Rectum [Howard W. Bruckner, John Pittrelli, Marnin Merrick]1472

104. Neoplasms of the Anus [Brenda Shank, Warren E. Enker, Marshall S. Flam]1521

Section 30 NEOPLASMS OF THE GENITOURINARY TRACT1530

105. Renal Cell Carcinoma [Jerome P. Richie, Philip W. Kantoff, Charles L. Shapiro]1530

106. Neoplasms of the Renal Pelvis and Ureter [Jerome P. Richie, Philip, W. Kantoff]1539

107. Bladder Cancer [Philip W. Kantoff, Anthony L. Zeitman, Kenneth Wishnow]1543

108. Neoplasms of the Prostate [William K. Oh, Mark Hurwitz, Anthony V. D Amico Jerome P. Richie, Philip W.Kantoff]1559

109. Neoplasms of the Penis [Victor A. Marcial, A. Puras, V.A. Marcial-Vega]1589

110. Neoplasms of the Testis [Craig R. Nichols, Robert Timmerman, Richard S. Foster, Bruce J. Roth, Lawrence H. Einhorn]1596

Section 31 NEOPLASMS OF THE FEMALE REPRODUCTIVE ORGANS1622

111. Neoplasms of the Vulva and Vagina [Jacob Rotmensch, Arthur L. Herbst]1622

112. Neoplasms of the Cervix [J. Taylor Wharton, Guillermo Tortolero-Luna]1631

113. Endometrial Cancer [Carmel J. Cohen, Gillian M. Thomas, George S. Hahopian]1667

114. Neoplasms of the Fallopian Tube [Carmel J. Cohen, Gillian M. Thomas, George S. Hagopian]1683

115. Ovarian Cancer [Jonathan S. Berek, Gillian M. Thomas. Robert F.Ozols]1687

116. Gestational Trophoblastic Disease [Ross S. Berkowitz, Donald P. Goldstein]1721

117. Gynecologic Sarcomas [Carmel J. Cohen, Gillian M. Thomas, George S. Hagopian]1727

Section 32 NEOPLASMS OF THE BREAST1735

118. Neoplasms of the Breast [Richard G. Margolese, Bernard Fisher, Gabriel N. Hortobagyi, William D. Bloomer]1735

Section 33 NEOPLASMS OF THE SKIN1823

119. Neoplasms of the Skin [Arthur K.F. Tong, Thomas B. Fitzpatrick]1823

Section 34 MALIGNANT MELANOMA1849

120. Malignant Melanoma [Donald L. Morton, Richard Essner, John M. Kirkwood, Robert C. Wollman]1849

Section 35 NEOPLASMS OF THE BONE AND SOFT TISSUE1870

121. Bone Tumors [Gerald Rosen, Charles A. Forscher, Henry, J. Mankin, Michael T. Selch]1870

122. Sarcomas of Nonosseous Tissues [Peter W.T. Pisters, Brian O Sullivan, George D. Demetri]1903

123. Myelodysplastic Syndrome [Lewis R. Silverman]1931

Section 36 NEOPLASMS OF THE HEMATOPOIETIC SYSTEM1931

124. Acute Myeloid Leukemia in Adults [Charles A. Schiffer, Richard M. Stone]1947

125. Chronic Myeloid Leukemia [Richard T. Silver]1971

126. Acute Lymphocytic Leukemia in Adults [Charles A. Schiffer, Richard A. Larson]1979

127. Chronic Lymphocytic Leukemia [Kanti R. Rai, Michael J. Keating]1989

128. Hairy-Cell Leudemia [Harvey M. Golomb, James Vardiman]2002

129. Hodgkin s Disease [Peter M. Mauch, James O. Armitage]2010

130. Non-Hodgkin s Lymphomas [Arnold S. Freedman, Lee M. Nadler]2034

131. Mycosis Fungoides and the Sezary Sydrome [Youn H. Kim, Richard T.Hoppe]2059

132. Plasma Cell Tumors [Kenneth C. Anderson]2066

133. Mast Cell Leukemia and Other Mast Cell Neoplasms [Richard M. Stone, Steven H. Bernstein]2086

134. Polycythemia Vera and Essential Thrombocythemia [Scott Murphy]2090

135. Neoplasms in Acquired Immunodeficiency Syndrome [David T. Scadden]2099

Section 37 NEOPLASMS IN AIDS2099

Section 38 NEOPLASMS OF UNKNOWN PRIMARY SITE2115

136. Neoplasms of Unknown Primary Site [John D. Hainsworth, F.Anthony Greco]2115

Section 39 NEOPLASMS IN CHILDREN2125

137a. Principles and Practice of Pediatric Oncology [Michael A. Weiner]2125

b. Incidence, Origins, Epidemiology [Leslie L. Robison]2128

c. Principles of Pediatric Radiation Oncology [John C. Breneman, Ashwatha Narayana]2131

d. Late Effects of Treatment of Cancer in Children and Adolescents [Daniel M. Green]2133

138a. Childhood Acute Lymphoblastic Leukemia [Paul S. Gaynon, Michael E. Trigg, Faith M. Uckun]2140

b. Pediatric Acute Myeloid Leukemia [Richard Aplenc, Beverly Lange]2151

c. Hodgkin s Disease in Children and Adolescents [Allen Chauvenet, Cindy L. Schwartz, Michael A.Weiner]2157

d. Non-Hodgkin s Lymphoma in Children [Mitchell S. Cairo, Sherrie Perkins]2162

e. Langerhans Cell Histiocytosis [Kara M. Kelly]2168

139a. Hepatic Tumors [Marcio Henrique Malogolowkin]2171

b. Renal Tumors of Childhood [Paul E. Grundy, Daniel M. Green, Norman E. Breslow, Michael L. Ritchey, Patrick R. M. Thomas]2174

c. Germ Cell Tumors [Barbara Cushing, Neyssa Marina]2181

d. Neuroblastoma [Katherine K. Matthay, Darrell J. Yamashiro]2185

e. Soft Tissue Sarcomas of Childhood [Leonard H. Wexler, Lee J. Helman]2198

Section 40 COMPLICATIONS OF CANCER AND ITS TREATMENT2204

140. Management of Cancer Pain [Alan c. Carver, Kathleen M. Foley]2204

141. Anorexia and Cachexia [Takao Ohnuma]2224

142. Antiemetic Therapy [Richard J. Gralla]2243

143. Neurologic Complications [Lisa M. DeAngelis, Jerome B. Posner]2251

144. Dermatologic Complications of Cancer Chemotherapy [Narin Apisarnthanarax, Madeleine Duvic]2271

145. Skeletal Complications [Samuel Kenan, Gabriel N. Hortobagyi]2279

146. Hematologic Complications and Blood Bank Support [Kenneth C. Anderson]2291

147. Coagulopathic Complications of Cancer [Sabine Eichinger, Kenneth A. Bauer]2309

148. Urologic Complications [Christopher J. Logothetis, Jose E. Sarriera]2317

149. Cardiac Complications [Michael S. Ewer, Robert S. Benjamin]2324

151. Liver Function and Hepatotoxicity in Cancer [Laurie D. DeLeve]2346

150. Respiratory Complications [Roy B.Jones]2359

152. Gastrointestinal Complications [Frank A. Sinicrope, Bernard Levin]2359

153. Oral Complications [Stephen T. Sonis]2371

154. Gonadal Complications [Catherine E. Klein]2380

155. Endocrine Complications [S. Jim Yeung, Robert F. Gagel]2389

156. Secondary Cancers: Incidence, Risk Factors, and Management [Susan R. Rheingold, Alfred I. Neugut, Anna T. Meadows]2399

Section 41 INFECTIONS IN PATIENTS WITH CANCER2407

157. Infections in Patients with Cancer [Kenneth V. I. Rolston, Gerald P. Brody]2407

Section 42 ONCOLOGIC EMERGENCIES2433

158. Oncologic Emergencies [John C. Morris, James F. Holland]2433

Section 43 ONCOLOGY AND THE INFORMATION REVOLUTION2454

159. Oncology and the Information Revolution [Edward P. Ambinder]2454

Index2469